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刘培庆

刘培庆,于1964年4月出生,医学博士,中山大学药学院教授来自、博士生导师,享受国务院政府特殊津贴专家,中山大学药理学国家重点学科带头人之一,中山大学卓越人才计划高层次人才,2016入选广东省特支计划杰出人才(南粤百杰),2017年广东省"珠江人才计划"本土创新科研团队负责人。现担任"新药成药性评估及评价国家360百科地方联合工程实验室(国家发展改革委扩陈了任示利带秋相授牌)"主任,国家新药成药性研究工程技术研究中心(培育)主任,国家重点培育平台"新药成药性研究武镇铁孩曲章没国家工程实验室"召集人,科技部"重大新药创制"药效学(心血管)平台组长,广东省新药成药性评估及评价工程实验室主任,广州市生物活性化合物成药性威要距乱必赶西补备评价重点实验室主任,2012年度"科学中国人"年度人物。担任中山大学药学院药理与毒理学实验室主任,新药束由包物例富社克研究开发中心主任。

  • 中文名称 刘培庆
  • 出生日期 1964年4月
  • 毕业院校 南京医科大学
  • 学位/学历 博士
  • 职务 中山大学药学院药理与毒理学实验室主任等

人物履历

  1985年毕业于山东省泰山医学院医疗系,获医学学士学位;

  1985年8~1987年8在山东省泰山医学院药理教研室担任助室准目供举教;

  1987年9月考入来自天津医科大学药理教研室攻读硕士研究生,

  1990年7月获硕士学位;

  1990年9~植初最下运好行当欢凯席1994年7 分别被聘为山东省泰360百科山医学院药理教研室讲师、副教授;

  1994年9月考入南京医科大学心血管药理研究室攻读博士研究生,

  1997年7月获博士学位;

  1997年9月~1999年7月在中山医科大学生理教研室从事博士后研究工作;

  1999年9月~2001年9月在中山医科大集放心学生理教研室副教授溶依社皮价排,并担任教研室副主任;

  2001年9月~200当良属能曾具为仅针2年6月调入中山大学中山医学院女边周张述故药理学教研室担任教研室副主任;

  2002年6月区非夜至今担任中山大学药学院副院长,药理毒理实验室主任。2004年起被聘任为教授。

研究方向

  主要从事心血管药理宽油算学及分子生物学研究,研居影试是伟担去语究方向为高血压心肌肥大的信号转导机制、比较蛋白质组学、动脉粥样硬化的发病机制及相关新药研究。

学术成果

科研项目

  先后主持国家自然科来自学基金8项、科技部"重大新药创制"科技重大专项3项、广东省自然科读国军病知创哥永绍眼学基金团队项目等3项,教育部及360百科广东省市重点重大项目10项,累计经费超过5千万元。

  近五年作为负责人承担或完成的项目,具体如下:

  1.国家自然科学基金面上项目,81872860,组蛋白去甲基化酶JMJD3调控病理性心肌肥大的表观修饰机制研究,2019/01-2022/12,60万元,在研,主持。

  2.广东省本土创新科研团队,2017BT01Y093,炎症相关性重大疾病创新药物研发及关键技术,2018-2023,1000万元,带头人。

  3.国家重大新药创制科技重大专项,2019ZX09301104,PDE9A抑十次候制剂LW33作为治疗阿尔茨海默病1.1类化学药的临床前研究,2019/01-2020/12,298.16万变记元,在研,主持。

  4.广东省产学研合作领域,2017B090903慢哪而湖灯批新004,国家新药成药性评价工程技术研究中心培育,杨农三压希了2017/01-2019/12,300万元,在研,主持。

  5.国家自然科就字巴生急学基金面上项目,81673433,FoxO3的PAR化修饰及其调控病规斗钟毛错呀否理性心肌肥大的机制,2017/01-2020/12,60万元,在研,主持。

  6.南粤百杰(广局病居久毛东省特支计划杰出人才),故印字赵派谁2016年,药理学,100他权验万。

  7.广州养带投剧市科技计划项目产学研协同创新重大专项,201604020121,选择性PDE9A抑制剂LW33治疗老年痴呆的临床前研究,2016/04-2019/03,200万元,申支两请结题,主持。

  8.广东省应用型科技研发专项资金项目,2015B020232009,PDE9A抑制剂LW33金城历呼别体走作为治疗阿尔兹海默病1.1类化学药的临床前研究,2016/01-2018/12,500万元,在研,主持。

  9.中山大学卓越人才计划高层次人才,2014年,药理学。

  10.国家自然科学改别级会师二香基金面上项目,81473205,从SIRT3调控角度研究病理性心肌肥大的能量代谢异常机制,2015/01-2018/12,80万元,已结题,主持。

  11.广东省科技厅公益研究与能力建设专项,2014B020210003,新药筛选及成药性评价关键技术味致宗层当抓见镇缺乎研究,2015/01-2017/12,100住身饭衣据肥措鱼整验庆万,已结题,主持。

  12.广东省创新载体建设项目,2013B090700010,新药成药性评估及药效学评价集成创新产学研平台,2014/01-2017/12,80万元,已结题,主持。

论著专利

  近年来发表SCI论文100多篇(累积影响因子超过500,他引超过5000次;通讯作者80多篇;通讯作者论文累计影响因子超过350,他引超过4000次)。以专利发明人或主要成员申请国家发明专利39项,其中21项已获授权。主编及参编专著8部。

  近5年以通讯作者发表的SCI论文:

  1. Fu Y#, Hong L#, Xu J#, Zhong G#, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C, Huang Z, Yin XM,Liu P*and Li M*. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo.Autophagy.2019;15:295-311.(IF: 11.06)
  2. Li J#, Huang J#, Lu J#, Guo Z, Li Z, Gao H, Wang P, Luo W, Cai S, Hu Y, Guo K, Wang L, Li Z, Wang M, Zhang X* andLiu PQ*. SIRT1 represses PKC-zeta activity via regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.Br J Pharmacol.2019;176:416-435.(IF: 6.58)
  3. Han Q#, Lv L#, Wei J#, Lei X, Lin H, Li G, Cao J, Xie J, Yang W, Wu S, You J, Lu J,Liu P*and Min J*. Vps4A mediates the localization and exosome release of beta-catenin to inhibit epithelial-mesenchymal transition in hepatocellular carcinoma.Cancer Lett.2019;457:47-59.(IF:6.51)
  4. Dai Q#, Zheng Z, Xia F,Liu P*and Li M*. A one-step specific assay for continuous detecting the activity of Sirtuin 2.Acta Pharmaceutica Sinica B.2019.(IF:5.81)
  5. Hu Y#, Guo Z#, Lu J*, Wang P, Sun S, Zhang Y, Li J, Zheng Q, Guo K, Wang J, Jiang J* andLiu PQ*. sFRP1 has a biphasic effect on doxorubicin-induced cardiotoxicity in a cellular location-dependent manner in NRCMs and Rats.Archives of Toxicology.2019;93:533-546.(IF: 5.74)
  6. Wang P#, Wang L, Lu J*, Hu Y, Wang Q, Li Z, Cai S, Liang L, Guo K, Xie J, Wang J, Lan R, Shen J* andLiu P*. SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function.J Mol Cell Cardiol.2019;133:125-137.(IF: 5.30)
  7. Zhang Y#, Lu W#, Zhang X, Lu J, Xu S, Chen S, Zhong Z, Zhou T, Wang Q, Chen J* andLiu P*. Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways.Pharmacol Res.2019:104307.(IF: 5.57)
  8. Liying Liang#, Yalin Tu, Jing Lu*, Panxia Wang, Zhen Guo, Qianqian Wang, Kaiteng Guo, Rui Lan, Hong Li,Peiqing Liu*, Dkk1 protects against doxorubicin-induced cardiotoxicity by inhibiting Wnt/β-catenin signaling pathway,Journal of Cell Science,2019. (IF: 4.52)
  9. Li ZZ#, Zhang XY, Guo Z, Zhong Y, Wang PX, Li JY, Li ZM andLiu PQ*. SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.Front Pharmacol.2019;9:14. (IF: 3.84)
  10. Sun DP#, Lu J#, Luo ZF, Zhang LY,Liu PQ*and Chen ZG*. Competitive electrochemical platform for ultrasensitive cytosensing of liver cancer cells by using nanotetrahedra structure with rolling circle amplification.Biosens Bioelectron.2018;120:8-14.(IF: 9.52)
  11. Lu J#, Li JY#, Hu YH, Guo Zhen, Duan DY, Sun DP, Wang PX, Guo KT, Gao S, Jiang JM, Wang Junjian* andLiu PQ*, Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation,Acta Pharmaceutica Sinica B,2018.(IF: 5.81)
  12. Luo WW#, Wang Y#, Yang HW, Dai CM, Hong HL, Li JY, Liu ZP, Guo Z, Chen XY, He P, Li ZQ, Li F, Jiang JM,Liu PQ*and Li ZM*. Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.Aging-Us.2018;10:1722-1744.(IF: 5.52)
  13. Guo Z#, Lu J, Li JY, Wang PX, Li ZZ, Zhong Y, Guo KT, Wang JJ, Ye JT* andLiu PQ*. JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing beta-MHC expression.Mol Cell Endocrinol.2018;477:1-14. (IF: 3.69)
  14. Wang LP#, Li ZM, Tan YZ, Li Q, Yang HW, Wang PX, Lu J* andLiu PQ*. PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.Mol Cell Endocrinol.2018;474:137-150. (IF: 3.69)
  15. Wen WJ#, Chen JW#, Ding LG#, Luo X, Zheng XP, Dai Q, Gu QQ, Liu C, Liang M, Guo XL,Liu PQ*and Li M.* Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy.Arch Biochem Biophys.2018;657:31-40. (IF: 3.56)
  16. Li ZM#, Xu SW# andLiu PQ*. Salvia miltiorrhiza Burge (Danshen): a golden herbal medicine in cardiovascular therapeutics.Acta pharmacologica Sinica.2018;39:802-824. (IF: 4.01)
  17. Li ST#, Dai Q, Zhang SX, Liu YJ, Yu QQ, Tan F, Lu SH, Wang Q, Chen JW, Huang HQ,Liu PQ*and Li M*. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-kappa B signaling pathway and activating the PI3K/Akt/Nrf2 pathway.Acta pharmacologica Sinica.2018;39:1294-1304. (IF: 4.01)
  18. Qian Li#, Zhuoming Li, Shuya Sun, Luping Wang, Panxia Wang, Zhen Guo, Hanwei Yang, Jiantao Ye, Jing Lu*,Peiqing Liu*, PARP1 interacts with HMGB1 and promotes its nucleus export in pathological myocardial hypertrophy,Acta Pharmacologica Sinica,2018, 0: 1-10. (IF: 4.01)
  19. Yang HW#, Hong HL, Luo WW, Dai CM, Chen XY, Wang LP, Li Q, Li ZQ,Liu PQ*and Li ZM*. mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3beta/C/EBPalpha signaling pathway.Acta pharmacologica Sinica. 2018;39:1837-1846. (IF: 4.01)
  20. He P#, Li ZM, Yue ZB, Gao H, Feng GS, Wang PX, Huang Y, Luo WW, Hong HQ, Liang LY, Chen SR* andLiu PQ*. SIRT3 prevents angiotensinⅡ-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.Molecular and Cellular Endocrinology.2018;460:1-13. (IF: 3.69)
  21. Gao S#, Liu XP, Wei LH, Lu J andLiu PQ*. Upregulation of alpha-enolase protects cardiomyocytes from phenylephrine-induced hypertrophy.Canadian journal of physiology and pharmacology.2018;96:352-358. (IF: 2.04)
  22. You J#, Yue Z, Chen S, Chen Y, Lu X, Zhang X, Shen P, Li J, Han Q, Li Z andLiu P*. Receptor-interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes.Acta Physiol.2017;220:58-71.(IF: 5.87)
  23. Chen YF#, Chen SR#, Yue ZB#, Zhang YQ, Zhou CH, Cao WW, Chen X, Zhang LK andLiu PQ*. Receptor-interacting protein 140 overexpression impairs cardiac mitochondrial function and accelerates the transition to heart failure in chronically infarcted rats.Translational Research.2017;180:91-102.(IF: 5.03)
  24. Wang PX#, Li ZM, Cai SD, Li JY, He P, Huang Y, Feng GS, Luo HB, Chen SR* andLiu PQ*. C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling.Acta pharmacologica Sinica.2017;38:1257-1268. (IF: 4.01)
  25. Feng GS#, Zhu CG, Li ZM, Wang PX, Huang Y, Liu M, He P, Lou LL, Chen SR* andLiu PQ*. Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensinⅡ-induced mouse cardiac remodeling.Acta pharmacologica Sinica.2017;38:638-650. (IF: 4.01)
  26. Lu J#, Zhang RW, Hong HQ, Yang ZL, Sun DP, Sun SY, Guo XL, Ye JT, Li ZM* andLiu PQ*. The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy.Biochimica Et Biophysica Acta-Molecular Cell Research. 2016;1863:3027-3039.(IF: 5.13)
  27. Lu J#, Sun DP, Liu ZP, Li M, Hong HQ, Liu C, Gao S, Li H, Cai Y, Chen SR, Li ZM, Ye JT* andLiu PQ*. SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.Translational Research. 2016;172:96-112.(IF: 5.03)
  28. Liu ZP#, Wang JJ, Huang XY, Li ZM* andLiu PQ*. Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice.Translational Research.2016;172:18-29.(IF: 5.03)
  29. Gao Y#, Liu YJ#, Hong L, Yang ZL, Cai XR, Chen XY, Fu YY, Lin YJ, Wen WJ, Li ST, Liu XG, Huang HQ, Vogt A,Liu PQ*, Yin XM* and Li M*. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy.Cell death & disease.2016;7.(IF: 5.95)
  30. Zhang XY#, Li W, Shen PY, Feng XJ, Yue ZB, Lu J, You J, Li JY, Gao H, Fang S, Li ZM* andLiu PQ*. STAT3 Suppression Is Involved in the Protective Effect of SIRT6 Against Cardiomyocyte Hypertrophy.Journal of Cardiovascular Pharmacology.2016;68:204-214. (IF: 2.37)
  31. Zhang BY#, Jiang JM, Yue ZB, Liu SL, Ma YZ, Yu N, Gao Y, Sun SY, Chen SR* andLiu PQ*. Store-Operated Ca2+Entry (SOCE) contributes to angiotensinⅡ-induced cardiac fibrosis in cardiac fibroblasts.Journal of Pharmacological Sciences.2016;132:171-180. (IF: 2.43)
  32. Yue ZB#, Ma YZ#, You J, Li ZM, Ding YQ, He P, Lu X, Jiang JM, Chen SR* andLiu PQ*. NMNAT3 is involved in the protective effect of SIRT3 in AngⅡ-induced cardiac hypertrophy.Experimental Cell Research.2016;347:261-273. (IF: 3.32)
  33. Shen PY#, Feng XJ, Zhang XY, Huang XY, Liu SL, Lu X, Li JY, You J, Lu J, Li ZM, Ye JT* andLiu PQ*. SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.Journal of Pharmacological Sciences.2016;132:31-40. (IF: 2.43)
  34. Li JY#, Gao H#, Huang JY, Wang PX, Huang Y, Luo WW, Zhang XY, Shen PY, You J, Cai SD, Li ZM* andLiu PQ*. PKC zeta interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy.Journal of Pharmacological Sciences.2016;132:15-23. (IF: 2.43)
  35. Wei JX#, Lv LH#, Wan YL#, Cao Y#, Li GL, Lin HM, Zhou R, Shang CZ, Cao J, He H, Han QF,Liu PQ*, Zhou G* and Min J*. Vps4A Functions as a Tumor Suppressor by Regulating the Secretion and Uptake of Exosomal MicroRNAs in Human Hepatoma Cells.Hepatology.2015;61:1284-1294.(IF: 14.97)
  36. Tan KM#, Liu ZP#, Wang JJ, Xu SW, You TH* andLiu PQ*. Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor kappa B signaling.Translational Research.2015;165:374-386.(IF: 5.03)
  37. Liu ZP#, Xu SW#, Huang XY, Wang JJ, Gao S, Li H, Zhou CH, Ye JT, Chen SR, Jin ZG andLiu PQ*. Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1).British Journal of Pharmacology.2015;172:5661-5675.(IF:6.58)
  38. Liu XP#, Gao H#, Huang XY, Chen YF, Feng XJ, He YH, Li ZM* andLiu PQ*. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway.Translational Research.2015;166:459-473.(IF: 5.03)
  39. Li Q#, Shen PY, Zeng SY andLiu PQ*. TIEG1 Inhibits AngiotensinⅡ-induced Cardiomyocyte Hypertrophy by Inhibiting Transcription Factor GATA4.Journal of Cardiovascular Pharmacology.2015;66:196-203. (IF:2.23)
  40. He YH#, Zhang LK, Li ZM, Gao H, Yue ZB, Liu ZP, Liu XP, Feng XJ andLiu PQ*. RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor.Febs Letters.2015;589:455-460. (IF:2.99)
  41. Gao S#, Li H#, Feng XJ, Li M, Liu ZP, Cai Y, Lu J, Huang XY, Wang JJ, Li Q, Chen SR, Ye JT* andLiu PQ*. alpha-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction.Journal of Molecular and Cellular Cardiology.2015;79:92-103.(IF:5.30)
  42. Gao H#, Feng XJ#, Li ZM#, Li M, Gao S, He YH, Wang JJ, Zeng SY, Liu XP, Huang XY, Chen SR* andLiu PQ*. Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides.Archives of Biochemistry and Biophysics.2015;565:76-88. (IF:3.56)
  43. Feng XJ#, Gao H#, Gao S, Li ZM, Li H, Lu J, Wang JJ, Huang XY, Liu M, Zou J, Ye JT* andLiu PQ*. The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1.British Journal of Pharmacology.2015;172:2852-2863.(IF:6.58)
  44. Cao WW#, Chen JW, Chen YF, Chen SR, Chen X, Huang HQ andLiu PQ*. Advanced glycation end products induced immune maturation of dendritic cells controls heart failure through NF-kappa B signaling pathway.Archives of Biochemistry and Biophysics.2015;580:112-120. (IF:3.56)
  45. Zou J#, Li H, Chen X, Zeng SY, Ye JT, Zhou CH, Liu M, Zhang LK, Yu N, Gan XH, Zhou HF, Xian ZW, Chen SR* andLiu PQ*. C/EBP beta knockdown protects cardiomyocytes from hypertrophy via inhibition of p65-NF kappa B.Molecular and Cellular Endocrinology.2014;390:18-25. (IF:3.69)
  46. Zhang LK#, Chen YF#, Yue ZB, He YH, Zou J, Chen SR, Liu M, Chen X, Liu ZP, Liu XP, Feng XJ, Li M andLiu PQ*. The p65 subunit of NF-kappa B involves in RIP140-mediated inflammatory and metabolic dysregulation in cardiomyocytes.Archives of Biochemistry and Biophysics.2014;554:22-27. (IF:3.56)
  47. Yu Y#, Chen SR#, Xiao CY, Jia YY, Guo JL, Jiang JM* andLiu PQ*. TRPM7 is involved in angiotensinⅡinduced cardiac fibrosis development by mediating calcium and magnesium influx.Cell Calcium.2014;55:252-260. (IF:3.93)
  48. Yu N#, Jiang JM, Yu Y, Li H, Huang XY, Ma YZ, Zhang LK, Zou J, Zhang BY, Chen SR* andLiu PQ*. SLC41A1 knockdown inhibits angiotensinⅡ-induced cardiac fibrosis by preventing Mg2+efflux and Ca2+signaling in cardiac fibroblasts.Archives of Biochemistry and Biophysics.2014;564:74-82. (IF:3.56)
  49. Xu SW*#, Liu ZP# andLiu PQ*. Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis.International Journal of Cardiology.2014;172:313-317. (IF:3.47)
  50. Xu SW*, Liu ZP, Huang Y, Chen JW, Chen SR, Shen XY, Huang HQ andLiu PQ*. Effectiveness of combination therapy of atorvastatin and non lipid-modifying tanshinoneⅡA from Danshen in a mouse model of atherosclerosis.International Journal of Cardiology.2014;174:878-880. (IF:3.47)
  51. Xu SW*, Bai P, Little PJ andLiu PQ*. Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications.Medicinal Research Reviews.2014;34:644-675.(IF:9.79)
  52. Wang JJ#, Liu ZP#, Feng XJ, Gao S, Xu SW andLiu PQ*. Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling.Archives of Biochemistry and Biophysics.2014;562:22-30. (IF:3.56)
  53. Ma YZ#, Li H, Yue ZB, Guo JL, Xu SW, Xu J, Jia YY, Yu N, Zhang BY, Liu SL, Liu M, Shao WW, Chen SR* andLiu PQ*. Cryptotanshinone Attenuates Cardiac Fibrosis via Downregulation of COX-2, NOX-2, and NOX-4.Journal of Cardiovascular Pharmacology.2014;64:28-37. (IF:2.37)
  54. Lu J#, Sun DP, Gao S, Gao Y, Ye JT* andLiu PQ*. Cyclovirobuxine D Induces Autophagy-Associated Cell Death via the Akt/mTOR Pathway in MCF-7 Human Breast Cancer Cells.Journal of Pharmacological Sciences.2014;125:74-82. (IF:2.44)
  55. Liu ZP#, Wang JJ, Huang EW, Gao S, Li H, Lu J, Tian KM, Little PJ, Shen XY, Xu SW* andLiu PQ*. TanshinoneⅡA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1.Journal of Lipid Research.2014;55:201-213. (IF:4.74)
  56. Liu M#, Ye JT, Gao S, Fang W, Li H, Geng BA, Zou J, Chen X, Chen SR, Zhang LK, Yue ZB, Ma YZ, Gao H, Li ZM* andLiu PQ*. Salvianolic acid B protects cardiomyocytes from angiotensinⅡ-induced hypertrophy via inhibition of PARP-1.Biochemical and Biophysical Research Communications.2014;444:346-353. (IF:2.71)
  57. Liu M#, Li Z#, Chen GW, Li ZM, Wang LP, Ye JT*, Luo HB* andLiu PQ*. AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngⅡ-induced hypertrophy.Molecular and Cellular Endocrinology.2014;392:14-22. (IF:3.56)
  58. Li H#, Gao S#, Ye JT, Feng XJ, Cai Y, Liu ZP, Lu J, Li Q, Huang XY, Chen SR* andLiu PQ*. COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: Role of NFATc3.Molecular and Cellular Endocrinology.2014;382:998-1006. (IF:3.69)
  59. Gao S#, Li H, Cai Y, Ye JT, Liu ZP, Lu J, Huang XY, Feng XJ, Gao H, Chen SR, Li M* andLiu PQ*. Mitochondrial binding of alpha-enolase stabilizes mitochondrial membrane: Its role in doxorubicin-induced cardiomyocyte apoptosis.Archives of Biochemistry and Biophysics.2014;542:46-55. (IF:3.56)
  60. Chen X#, Zeng SY, Zou J, Chen YF, Yue ZB, Gao Y, Zhang LK, Cao WW andLiu PQ*. Rapamycin Attenuated Cardiac Hypertrophy Induced by Isoproterenol and Maintained Energy Homeostasis via Inhibiting NF-kappa B Activation.Mediators of Inflammation.2014.(IF:3.55)
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  62. 刘培庆等。中国发明专利申请。一种防治缺血性脑中风的磷酸二酯酶9A抑制剂的用途;申请号:201910550380.9,公布日:2019-06-24。
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  70. 黄河清,刘培庆等。中国发明专利授权。一种治疗糖尿病的药物组合物及其制备方法,申请号200510101169.7,公告号CN100336526 C,授权号:ZL 200510101169.7,授权日2007.09.12,成功转让并已进入3期临床试验。 近5年主编及参编专著:1、参编《心脑血管药理学》.主笔《治疗心力衰竭的药物》一章,约3万字. 科学出版社,2019年3月出版。2、参编《高等药理学》.主笔第六篇第二章《心力衰竭治疗药物》,2万字. 校稿中,预计2019年出版。3、主编《药理学实验实训教程》. 科学出版社,2015年6月出版,ISBN 978-7- 03-044688-6.4、参编"国家卫生和计划生育委员会"十三五"规划教材、全国高等医药教材建设研究会"十三五"规划教材"《药理学(第8版)》. 人民卫生出版社,主编:朱依谆、殷明,2016年8月出版。主笔"抗动脉粥样硬化药物"一章,共1.5万字。

社会兼职

  现任全国转化医学产业学会副会长、中国整合药学联盟副理事长,中国药理学会理事、广东省药理学会理事长、广东省人事厅博士后协会(联谊会)理事长、中国药理学会表观遗传药理学专业委员会副主委,粤港澳大湾区新药产业化联盟副主席,以及心血管药理等3个专业委员会常委等。担任国家科学技术奖评奖专家、国家重大专项审评专家、国家自然科学基金二审专家及教育部专项审评专家,广东省重大行政决策咨询论证专家、广东省市科技项目、科学技术奖及新药审评论证专家等,广东省知识产权局第二届广东专利奖评审委员会医药评审组组长。担任《中华现代内科学杂志》常务编委、《药学研究》、《药学实践》等杂志编委等。兼任华南理工大学讲座教授、广州中医药大学客座教授等。

获奖记录

  获得广东省科学技术一等奖、教育部科技成果二等奖(主要成员),广东省科学技术一等奖(第一完成人),以专利发明人或主要成员申请国家发明专利39项,其中21项已获授权。Circulation ResBr J PharmacolOncogeneExp Cell ResActa Pharm Sin BInflammation等杂志审稿人。指导博士研究生40多名,硕士研究生100多名,已毕业者全部获得硕士学位,毕业的博生基本都获得了国家自然科学基金资助,还获得了广东特支计划青年优秀人才、羊城学者、珠江新星等荣誉。

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